| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50257758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562700 (CHEMBL1012735) |
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| IC50 | >30±n/a nM |
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| Citation |  Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:2048-52 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52505.96 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_852948 |
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| Residue: | 447 |
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| Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
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| BDBM50257758 |
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| n/a |
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| Name | BDBM50257758 |
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| Synonyms: | 3-(2-(4-methoxyphenyl)-3-oxo-6-(3-(trifluoromethyl)benzylamino)pyrido[2,3-b]pyrazin-4(3H)-yl)propanamide | CHEMBL521993 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F3N5O3 |
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| Mol. Mass. | 497.4691 |
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| SMILES | COc1ccc(cc1)-c1nc2ccc(NCc3cccc(c3)C(F)(F)F)nc2n(CCC(N)=O)c1=O |
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| Structure | 
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