Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50286984 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_159467 |
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pH | 4.7±n/a |
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IC50 | 262±n/a nM |
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Comments | extracted |
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Citation | Steinbaugh, BA; Hamilton, HW; Prasad, JV; Para, KS; J., TP; Ferguson, D; Lunney, EA; Blankley, CJ A topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxy-pyran-2-ones Bioorg Med Chem Lett6:1099-1104 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50286984 |
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n/a |
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Name | BDBM50286984 |
Synonyms: | 6-(3-Ethyl-phenyl)-4-hydroxy-3-(2-isopropyl-phenylsulfanyl)-pyran-2-one | CHEMBL12229 |
Type | Small organic molecule |
Emp. Form. | C22H22O3S |
Mol. Mass. | 366.473 |
SMILES | CCc1cccc(c1)-c1cc(O)c(Sc2ccccc2C(C)C)c(=O)o1 |
Structure |
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