| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Ligand | BDBM50290427 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161903 (CHEMBL767982) |
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| IC50 | >500000±n/a nM |
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| Citation |  Zimmermann, J; Buchdunger, E; Mett, H; Meyer, T; Lydon, NB Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives Bioorg Med Chem Lett7:187-192 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Name: | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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| Synonyms: | cAMP-dependent protein kinase (PKA) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 217489 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | cAMP-dependent protein kinase catalytic subunit beta |
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| Synonyms: | KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40631.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586348 |
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| Residue: | 351 |
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| Sequence: | MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
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| Component 2 |
| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
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| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
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| Type: | Enzyme Catalytic Subunit |
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| Mol. Mass.: | 40598.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| Component 3 |
| Name: | cAMP-dependent protein kinase catalytic subunit gamma |
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| Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40442.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104720 |
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| Residue: | 351 |
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| Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
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| BDBM50290427 |
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| n/a |
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| Name | BDBM50290427 |
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| Synonyms: | CHEMBL56359 | Thiophene-2-carboxylic acid [3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N5OS |
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| Mol. Mass. | 373.431 |
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| SMILES | O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccs1 |
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| Structure | 
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