| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50293876 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_572639 (CHEMBL1026063) |
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| IC50 | 300±n/a nM |
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| Citation |  Gibson, C; Schnatbaum, K; Pfeifer, JR; Locardi, E; Paschke, M; Reimer, U; Richter, U; Scharn, D; Faussner, A; Tradler, T Novel small molecule bradykinin B2 receptor antagonists. J Med Chem52:4370-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44467.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
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| Residue: | 391 |
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| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
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| BDBM50293876 |
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| n/a |
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| Name | BDBM50293876 |
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| Synonyms: | 8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-4-yl-quinoline | CHEMBL550143 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13Cl2N3OS |
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| Mol. Mass. | 402.297 |
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| SMILES | Cc1cc(-c2cscn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 |
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| Structure | 
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