Ki Summary

Reaction Details

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Target

Adenosine receptor A3

Ligand

BDBM50082419

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_587704 (CHEMBL1037718)

19.81±n/a nM

Citation

Michielan, L; Bolcato, C; Federico, S; Cacciari, B; Bacilieri, M; Klotz, KN; Kachler, S; Pastorin, G; Cardin, R; Sperduti, A; Spalluto, G; Moro, S Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. Bioorg Med Chem17:5259-74 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A3

Name:

Adenosine receptor A3

Synonyms:

A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36197.32

Organism:

Homo sapiens (Human)

Description:

P0DMS8

Residue:

318

Sequence:

MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

BDBM50082419

n/a

Name

BDBM50082419

Synonyms:

1-(2-(furan-2-yl)-8-(3-phenylpropyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea | 1-[2-Furan-2-yl-8-(3-phenyl-propyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-3-(4-methoxy-phenyl)-urea | CHEMBL139182

Type

Small organic molecule

Emp. Form.

C27H24N8O3

Mol. Mass.

508.5313

SMILES

COc1ccc(NC(=O)Nc2nc3nn(CCCc4ccccc4)cc3c3nc(nn23)-c2ccco2)cc1

Structure