| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50316412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_628088 (CHEMBL1107316) |
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| IC50 | 340±n/a nM |
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| Citation |  Tangeda, SJ; Garlapati, A Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines. Eur J Med Chem45:1453-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50316412 |
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| n/a |
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| Name | BDBM50316412 |
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| Synonyms: | 2-amino-4-oxo-5-thiopyridyl-6-methyl pyrrolo(2,3-d)pyrimidine | CHEMBL1096259 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N4OS |
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| Mol. Mass. | 272.326 |
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| SMILES | Cc1[nH]c2nc(C)[nH]c(=O)c2c1Sc1ccncc1 |
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| Structure | 
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