Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50328347 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_665508 (CHEMBL1261339) |
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IC50 | 920±n/a nM |
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Citation | Fox, BM; Iio, K; Li, K; Choi, R; Inaba, T; Jackson, S; Sagawa, S; Shan, B; Tanaka, M; Yoshida, A; Kayser, F Discovery of pyrrolopyridazines as novel DGAT1 inhibitors. Bioorg Med Chem Lett20:6030-3 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT |
Type: | Multi-pass membrane protein may form homo- or heterodimers. |
Mol. Mass.: | 64751.94 |
Organism: | Homo sapiens (Human) |
Description: | P35610 |
Residue: | 550 |
Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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BDBM50328347 |
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n/a |
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Name | BDBM50328347 |
Synonyms: | CHEMBL1257800 | diethyl 2-morpholino-4-phenyl-7-(3,3,3-trifluoropropyl)pyrrolo[1,2-b]pyridazine-5,6-dicarboxylate |
Type | Small organic molecule |
Emp. Form. | C26H28F3N3O5 |
Mol. Mass. | 519.5128 |
SMILES | CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1 |
Structure |
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