| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50338532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728487 (CHEMBL1685364) |
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| IC50 | 33±n/a nM |
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| Citation |  Atkinson, KA; Beretta, EE; Brown, JA; Castrodad, M; Chen, Y; Cosgrove, JM; Du, P; Litchfield, J; Makowski, M; Martin, K; McLellan, TJ; Neagu, C; Perry, DA; Piotrowski, DW; Steppan, CM; Trilles, R N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett21:1621-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50338532 |
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| n/a |
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| Name | BDBM50338532 |
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| Synonyms: | 1-(4-chloro-3-(trifluoromethyl)benzyl)-N-(1-methyl-1H-pyrazol-3-yl)-1H-1,2,3-triazole-4-carboxamide | CHEMBL1683587 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12ClF3N6O |
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| Mol. Mass. | 384.744 |
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| SMILES | Cn1ccc(NC(=O)c2cn(Cc3ccc(Cl)c(c3)C(F)(F)F)nn2)n1 |
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| Structure | 
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