| Reaction Details |
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 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Ligand | BDBM53035 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756675 (CHEMBL1805140) |
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| IC50 | 11000±n/a nM |
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| Citation |  Bryk, R; Wu, K; Raimundo, BC; Boardman, PE; Chao, P; Conn, GL; Anderson, E; Cole, JL; Duffy, NP; Nathan, C; Griffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett21:4108-14 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interferon-induced, double-stranded RNA-activated protein kinase |
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| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62104.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467743 |
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| Residue: | 551 |
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| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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| BDBM53035 |
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| n/a |
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| Name | BDBM53035 |
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| Synonyms: | 4-[(3-methyl-5-oxo-4-pyrazolyl)hydrazo]benzenesulfonamide | 4-[2-(3-methyl-5-oxidanylidene-pyrazol-4-yl)hydrazinyl]benzenesulfonamide | 4-[2-(3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazino]benzenesulfonamide | 4-[2-(3-methyl-5-oxopyrazol-4-yl)hydrazinyl]benzenesulfonamide | 4-[N'-(3-keto-5-methyl-pyrazol-4-yl)hydrazino]benzenesulfonamide | CHEMBL1802490 | MLS001180102 | SMR000477098 | cid_5349084 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11N5O3S |
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| Mol. Mass. | 281.291 |
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| SMILES | Cc1[nH][nH]c(=O)c1N=Nc1ccc(cc1)S(N)(=O)=O |w:8.9| |
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| Structure | 
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