Reaction Details |
| Report a problem with these data |
Target | Seed linoleate 13S-lipoxygenase-1 |
---|
Ligand | BDBM24513 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_791246 (CHEMBL1929733) |
---|
IC50 | 116000±n/a nM |
---|
Citation | Eleftheriou, P; Geronikaki, A; Hadjipavlou-Litina, D; Vicini, P; Filz, O; Filimonov, D; Poroikov, V; Chaudhaery, SS; Roy, KK; Saxena, AK Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors. Eur J Med Chem47:111-24 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Seed linoleate 13S-lipoxygenase-1 |
---|
Name: | Seed linoleate 13S-lipoxygenase-1 |
Synonyms: | 15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1 |
Type: | Enzyme |
Mol. Mass.: | 94365.66 |
Organism: | Glycine max (soybean) |
Description: | n/a |
Residue: | 839 |
Sequence: | MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGK
DTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQ
GTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEY
DRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYV
PRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLP
RDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIR
GLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQI
NQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWL
LAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINA
LARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHG
VRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDL
KDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGT
PEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQ
AFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
|
|
|
BDBM24513 |
---|
n/a |
---|
Name | BDBM24513 |
Synonyms: | (2E,5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one | Thiazole analogue, 1 |
Type | Small organic molecule |
Emp. Form. | C13H9N3O2S2 |
Mol. Mass. | 303.359 |
SMILES | Oc1ccc(\C=C2\S\C(NC2=O)=N\c2nccs2)cc1 |
Structure |
|