Reaction Details |
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Target | Kynurenine--oxoglutarate transaminase 1 |
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Ligand | BDBM50004956 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_804058 (CHEMBL1952453) |
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IC50 | 293000±n/a nM |
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Citation | Akladios, FN; Nadvi, NA; Park, J; Hanrahan, JR; Kapoor, V; Gorrell, MD; Church, WB Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorg Med Chem Lett22:1579-81 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine--oxoglutarate transaminase 1 |
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Name: | Kynurenine--oxoglutarate transaminase 1 |
Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
Type: | Aminotransferase; Lyase |
Mol. Mass.: | 47874.00 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
Residue: | 422 |
Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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BDBM50004956 |
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n/a |
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Name | BDBM50004956 |
Synonyms: | 3-(2-Carboxy-ethyl)-5-chloro-1H-indole-2-carboxylic acid | CHEMBL417544 |
Type | Small organic molecule |
Emp. Form. | C12H10ClNO4 |
Mol. Mass. | 267.665 |
SMILES | OC(=O)CCc1c([nH]c2ccc(Cl)cc12)C(O)=O |
Structure |
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