Ki Summary

Reaction Details

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Target

B2 bradykinin receptor

Ligand

BDBM50286384

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_40427

17900±n/a nM

Citation

Salvino, JM; Seoane, PR; Douty, BD; Awad, MA; Hoyer, D; Ross, TM; Dolle, RE; Houck, WT; Faunce, DM; Sawutz, DG Structure activity relationships of non-peptide bradykinin B2 receptor antagonists Bioorg Med Chem Lett5:357-362 (1995) Article

More Info.:

Get all data from this article, Assay Method

B2 bradykinin receptor

Name:

B2 bradykinin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44467.17

Organism:

Homo sapiens (Human)

Description:

B2 BRADYKININ BDKRB2 HUMAN::P30411

Residue:

391

Sequence:

MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ

BDBM50286384

n/a

Name

BDBM50286384

Synonyms:

N-(2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionamide

Type

Small organic molecule

Emp. Form.

C46H58N5O

Mol. Mass.

696.9851

SMILES

O=C(NC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)[C@H](Cc1ccc2ccccc2c1)N\C(NC1CCCCC1)=[NH+]\C1CCCCC1 |wD:24.41,(14.19,-7.67,;14.04,-9.21,;15.29,-10.12,;16.83,-10.12,;17.59,-8.79,;18.92,-9.56,;17.82,-10.64,;19.16,-11.41,;19.9,-10.12,;19.13,-8.79,;17.59,-11.46,;17.58,-13,;16.25,-13.75,;14.92,-12.98,;13.57,-13.73,;13.56,-15.27,;14.9,-16.06,;16.23,-15.29,;18.92,-13.75,;20.25,-13,;21.58,-13.75,;21.58,-15.32,;20.23,-16.09,;18.9,-15.32,;12.63,-9.84,;12.46,-11.39,;11.36,-12.46,;12.14,-13.8,;11.39,-15.13,;9.84,-15.13,;9.1,-16.46,;7.56,-16.46,;6.78,-15.15,;7.55,-13.82,;9.07,-13.8,;9.83,-12.49,;11.37,-8.93,;9.87,-8.53,;8.78,-9.61,;7.23,-9.61,;6.48,-10.99,;4.75,-10.47,;3.58,-10.85,;4.47,-9.61,;5.92,-10.1,;9.48,-7.04,;7.98,-6.64,;6.66,-7.11,;5.22,-6.62,;4.33,-7.88,;5.49,-7.49,;7.22,-8.02,)|

Structure