Reaction Details |
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Target | Prostaglandin G/H synthase 1 |
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Ligand | BDBM50145504 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_159257 |
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IC50 | 21000±n/a nM |
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Citation | Jahng, Y; Zhao, LX; Moon, YS; Basnet, A; Kim, EK; Chang, HW; Ju, HK; Jeong, TC; Lee, ES Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities. Bioorg Med Chem Lett14:2559-62 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 |
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Name: | Prostaglandin G/H synthase 1 |
Synonyms: | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_MOUSE | PGHS-1 | PHS 1 | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1 |
Type: | PROTEIN |
Mol. Mass.: | 69044.61 |
Organism: | Mus musculus |
Description: | ChEMBL_10575 |
Residue: | 602 |
Sequence: | MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCD
CTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLT
VRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLA
QQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSF
QELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRST
EL
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BDBM50145504 |
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n/a |
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Name | BDBM50145504 |
Synonyms: | (E)-3-Furan-3-yl-1-pyridin-3-yl-propenone | CHEMBL315421 |
Type | Small organic molecule |
Emp. Form. | C12H9NO2 |
Mol. Mass. | 199.2054 |
SMILES | O=C(\C=C\c1ccoc1)c1cccnc1 |
Structure |
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