Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50106597

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_40037 (CHEMBL653018)

IC50

>10000±n/a nM

Citation

Bartolomé-Nebreda, JM; García-López, MT; González-Muñiz, R; Cenarruzabeitia, E; Latorre, M; Del Río, J; Herranz, R 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold. J Med Chem44:4196-206 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48980.43

Organism:

RAT

Description:

Cholecystokinin A CCKBR RAT::P30553

Residue:

452

Sequence:

MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50106597

n/a

Name

BDBM50106597

Synonyms:

CHEMBL133983 | [1-(2-Benzyl-1-oxo-3-thioxo-octahydro-4a(S)-pyrido[1,2-c]pyrimidin-5(R)-ylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Type

Small organic molecule

Emp. Form.

C31H37N5O4S

Mol. Mass.

575.722

SMILES

CC(C)(C)OC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2[C@H]1CC(=S)N(Cc1ccccc1)C2=O

Structure