| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Ligand | BDBM50373700 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_468301 (CHEMBL930592) |
|---|
| IC50 | 44±n/a nM |
|---|
| Citation |  Laplante, Y; Cadot, C; Fournier, MA; Poirier, D Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone. Bioorg Med Chem16:1849-60 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34945.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14061 |
|---|
| Residue: | 328 |
|---|
| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
|
|
|
|---|
| BDBM50373700 |
|---|
| n/a |
|---|
| Name | BDBM50373700 |
|---|
| Synonyms: | CHEMBL410242 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31NO3 |
|---|
| Mol. Mass. | 405.5292 |
|---|
| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@H](Cc1cccc(c1)C(N)=O)[C@@H]2O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
