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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50275319 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_496147 (CHEMBL1000136) | ||
| Ki | 183±n/a nM | ||
| Citation |  Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem51:7523-31 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46445.29 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Binding assays were performed using rat hippocampal membranes. | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50275319 | |||
| n/a | |||
| Name | BDBM50275319 | ||
| Synonyms: | CHEMBL485728 | cis-1-(4-(3-methoxyphenyl)cyclohexyl)-4-phenylpiperazine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H30N2O | ||
| Mol. Mass. | 350.4971 | ||
| SMILES | COc1cccc(c1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccc1 |r,wU:8.8,11.15,(21.08,-16.94,;22.41,-16.17,;22.41,-14.63,;21.08,-13.86,;21.08,-12.32,;22.41,-11.55,;23.74,-12.31,;23.75,-13.86,;25.07,-11.53,;26.41,-12.3,;27.73,-11.53,;27.73,-9.99,;26.4,-9.22,;25.06,-10,;29.06,-9.22,;30.39,-10,;31.72,-9.23,;31.73,-7.69,;30.4,-6.92,;29.06,-7.69,;33.07,-6.93,;33.06,-5.4,;34.39,-4.63,;35.73,-5.4,;35.73,-6.94,;34.39,-7.71,)| | ||
| Structure | 
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