Ki Summary

Reaction Details

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Target

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Ligand

BDBM50275319

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_496150 (CHEMBL1000139)

1710±n/a nM

Citation

Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem51:7523-31 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Name:

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Synonyms:

EBP | EBP_CAVPO

Type:

PROTEIN

Mol. Mass.:

26684.52

Organism:

Cavia porcellus

Description:

ChEMBL_203193

Residue:

229

Sequence:

MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLG
TWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFII
CMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEM
GHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK

BDBM50275319

n/a

Name

BDBM50275319

Synonyms:

CHEMBL485728 | cis-1-(4-(3-methoxyphenyl)cyclohexyl)-4-phenylpiperazine

Type

Small organic molecule

Emp. Form.

C23H30N2O

Mol. Mass.

350.4971

SMILES

COc1cccc(c1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccc1 |r,wU:8.8,11.15,(21.08,-16.94,;22.41,-16.17,;22.41,-14.63,;21.08,-13.86,;21.08,-12.32,;22.41,-11.55,;23.74,-12.31,;23.75,-13.86,;25.07,-11.53,;26.41,-12.3,;27.73,-11.53,;27.73,-9.99,;26.4,-9.22,;25.06,-10,;29.06,-9.22,;30.39,-10,;31.72,-9.23,;31.73,-7.69,;30.4,-6.92,;29.06,-7.69,;33.07,-6.93,;33.06,-5.4,;34.39,-4.63,;35.73,-5.4,;35.73,-6.94,;34.39,-7.71,)|

Structure