Ki Summary

Reaction Details

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Target

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Ligand

BDBM50274944

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_496150 (CHEMBL1000139)

85±n/a nM

Citation

Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem51:7523-31 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Name:

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Synonyms:

EBP | EBP_CAVPO

Type:

PROTEIN

Mol. Mass.:

26684.52

Organism:

Cavia porcellus

Description:

ChEMBL_203193

Residue:

229

Sequence:

MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLG
TWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFII
CMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEM
GHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK

BDBM50274944

n/a

Name

BDBM50274944

Synonyms:

CHEMBL458802 | cis-4-[4-(2-Chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine

Type

Small organic molecule

Emp. Form.

C21H26ClN3

Mol. Mass.

355.904

SMILES

Clc1ccccc1[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:7.7,10.14,(2.07,.71,;2.07,-.83,;.74,-1.6,;.74,-3.14,;2.07,-3.92,;3.41,-3.14,;3.41,-1.59,;4.74,-.81,;6.07,-1.58,;7.4,-.81,;7.4,.73,;6.06,1.5,;4.73,.72,;8.73,1.5,;10.06,.72,;11.39,1.48,;11.4,3.02,;10.06,3.8,;8.72,3.03,;12.73,3.79,;12.73,5.32,;14.06,6.09,;15.4,5.32,;15.39,3.77,;14.06,3.01,)|

Structure