| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM50028962 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_519008 (CHEMBL942569) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Dong, CK; Patel, V; Yang, JC; Dvorin, JD; Duraisingh, MT; Clardy, J; Wirth, DF Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett19:972-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 65581.88 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | His6-tag DHODH was expressed in E. coli. |
|---|
| Residue: | 569 |
|---|
| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
|
|
|
|---|
| BDBM50028962 |
|---|
| n/a |
|---|
| Name | BDBM50028962 |
|---|
| Synonyms: | CHEMBL275638 | flavone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10O2 |
|---|
| Mol. Mass. | 222.2387 |
|---|
| SMILES | O=c1cc(oc2ccccc12)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
