| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50265355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496793 (CHEMBL1008806) |
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| Ki | 2740±n/a nM |
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| Citation |  Cao, J; Kopajtic, T; Katz, JL; Newman, AH Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. Bioorg Med Chem Lett18:5238-41 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69236.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q63380 |
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| Residue: | 617 |
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| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50265355 |
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| n/a |
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| Name | BDBM50265355 |
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| Synonyms: | 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropyl 2-phenylacetate | CHEMBL505059 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H39F2N3O2 |
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| Mol. Mass. | 583.7106 |
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| SMILES | Fc1ccc(cc1)N(CCCN1CCN(CCC(OC(=O)Cc2ccccc2)c2ccccc2)CC1)c1ccc(F)cc1 |
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| Structure | 
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