| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM50322163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_642500 (CHEMBL1175873) |
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| Ki | 26.3±n/a nM |
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| Citation |  Ivachtchenko, AV; Golovina, ES; Kadieva, MG; Koryakova, AG; Kovalenko, SM; Mitkin, OD; Okun, IM; Ravnyeyko, IM; Tkachenko, SE; Zaremba, OV Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists. Bioorg Med Chem18:5282-90 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM50322163 |
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| n/a |
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| Name | BDBM50322163 |
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| Synonyms: | 10-(benzenesulfonyl)-N-(3,5-dimethyladamantan-1- yl)-5-thia-1,8,11,12- tetraazatricyclo[7.3.0.0^{2,6}]dodeca- 2(6),3,7,9,11-pentaen-7-amine | CHEMBL1173209 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N5O2S2 |
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| Mol. Mass. | 493.644 |
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| SMILES | CC12CC3CC(C)(C1)CC(C3)(C2)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccccc1 |TLB:4:3:11:7.5.8,4:5:2.3.10:11,12:9:2:7.4.5,THB:8:5:2:10.9.11,8:9:2:7.4.5,6:5:2:10.9.11,6:5:2.3.10:11| |
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| Structure | 
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