Reaction Details |
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Target | Fructose-1,6-bisphosphatase 1 |
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Ligand | BDBM50335083 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_702737 (CHEMBL1657811) |
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IC50 | 16±n/a nM |
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Citation | Fan, Y; Jiang, T; Cashion, DK; Sun, Z; Tian, F; DaRe, J; Lemus, R Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. J Med Chem54:153-65 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fructose-1,6-bisphosphatase 1 |
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Name: | Fructose-1,6-bisphosphatase 1 |
Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
Type: | Protein |
Mol. Mass.: | 36843.58 |
Organism: | Homo sapiens (Human) |
Description: | Liver FBPase (P09467) |
Residue: | 338 |
Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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BDBM50335083 |
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n/a |
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Name | BDBM50335083 |
Synonyms: | 2-Amino-4-[2-(5-phosphono)furanyl]-5-propylsulfanylthiazole | 5-(2-amino-5-(propylthio)thiazol-4-yl)furan-2-ylphosphonic acid | CHEMBL509861 |
Type | Small organic molecule |
Emp. Form. | C10H13N2O4PS2 |
Mol. Mass. | 320.325 |
SMILES | CCCSc1sc(N)nc1-c1ccc(o1)P(O)(O)=O |
Structure |
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