Reaction Details |
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Target | Vitamin D3 receptor |
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Ligand | BDBM50389852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_834839 (CHEMBL2073156) |
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IC50 | 4400±n/a nM |
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Citation | Nandhikonda, P; Lynt, WZ; McCallum, MM; Ara, T; Baranowski, AM; Yuan, NY; Pearson, D; Bikle, DD; Guy, RK; Arnold, LA Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem55:4640-51 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin D3 receptor |
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Name: | Vitamin D3 receptor |
Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
Type: | Protein |
Mol. Mass.: | 48288.72 |
Organism: | Homo sapiens (Human) |
Description: | P11473 |
Residue: | 427 |
Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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BDBM50389852 |
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n/a |
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Name | BDBM50389852 |
Synonyms: | CHEMBL2070874 |
Type | Small organic molecule |
Emp. Form. | C22H18ClN3O2 |
Mol. Mass. | 391.85 |
SMILES | Cc1[nH]c2ccccc2c1C(Nc1ccc(cc1)[N+]([O-])=O)c1ccccc1Cl |
Structure |
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