| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin reductase 1 |
|---|
| Ligand | BDBM50410833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_341692 (CHEMBL861403) |
|---|
| IC50 | 95±n/a nM |
|---|
| Citation |  Gong, J; Neels, JF; Yu, X; Kensler, TW; Peterson, LA; Sturla, SJ Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. J Med Chem49:2593-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin reductase 1 |
|---|
| Name: | Prostaglandin reductase 1 |
|---|
| Synonyms: | Dig1 | Ltb4dh | NADP-dependent leukotriene B4 12-hydroxydehydrogenase | PTGR1_RAT | Ptgr1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35721.48 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_341692 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MVQAKTWTLKKHFEGFPTDSNFELRTTELPPLNNGEVLLEALFLSVDPYMRVAAKKLKEG
DSMMGEQVARVVESKNSAFPTGTIVVALLGWTSHSISDGNGLRKLPAEWPDKLPLSLALG
TVGMPGLTAYFGLLDICGLKGGETVLVNAAAGAVGSVVGQIAKLKGCKVVGTAGSDEKVA
YLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNVGGEFSNTVILQMKTFGRIAICG
AISQYNRTGPCPPGPSPEVIIYQQLRMEGFIVTRWQGEVRQKALTDLMNWVSEGKIRYHE
YITEGFEKMPAAFMGMLKGDNLGKTIVKA
|
|
|
|---|
| BDBM50410833 |
|---|
| n/a |
|---|
| Name | BDBM50410833 |
|---|
| Synonyms: | ACYLFULVENE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16O2 |
|---|
| Mol. Mass. | 216.2756 |
|---|
| SMILES | CC1=CC2=C(C)[C@]3(CC3)[C@@](C)(O)C(=O)C2=C1 |r,c:3,16,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
