| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM50410956 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_364093 (CHEMBL869037) |
|---|
| IC50 | 63.1±n/a nM |
|---|
| Citation |  Nelson, DW; Gregg, RJ; Kort, ME; Perez-Medrano, A; Voight, EA; Wang, Y; Grayson, G; Namovic, MT; Donnelly-Roberts, DL; Niforatos, W; Honore, P; Jarvis, MF; Faltynek, CR; Carroll, WA Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem49:3659-66 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68403.50 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q64663 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
|
|
|
|---|
| BDBM50410956 |
|---|
| n/a |
|---|
| Name | BDBM50410956 |
|---|
| Synonyms: | CHEMBL437703 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H9ClF3N5 |
|---|
| Mol. Mass. | 339.703 |
|---|
| SMILES | FC(F)(F)c1cccc(-c2nnnn2Cc2cccnc2)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
