| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
|---|
| Ligand | BDBM50416872 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_664241 (CHEMBL1261748) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Jaroch, S; Berger, M; Huwe, C; Krolikiewicz, K; Rehwinkel, H; Schäcke, H; Schmees, N; Skuballa, W Discovery of quinolines as selective glucocorticoid receptor agonists. Bioorg Med Chem Lett20:5835-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mineralocorticoid receptor |
|---|
| Name: | Mineralocorticoid receptor |
|---|
| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 107076.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08235 |
|---|
| Residue: | 984 |
|---|
| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
|
|
|
|---|
| BDBM50416872 |
|---|
| n/a |
|---|
| Name | BDBM50416872 |
|---|
| Synonyms: | CHEMBL1257342 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23F4NO2 |
|---|
| Mol. Mass. | 421.4278 |
|---|
| SMILES | CC(C)(CC(O)(CNc1cccc2ccccc12)C(F)(F)F)c1cc(F)ccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
