Ki Summary

Reaction Details

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Target

Phospholipase A2, membrane associated

Ligand

BDBM50428492

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_943475 (CHEMBL2342415)

IC50

217000±n/a nM

Citation

Ye, L; Dickerson, T; Kaur, H; Takada, YK; Fujita, M; Liu, R; Knapp, JM; Lam, KS; Schore, NE; Kurth, MJ; Takada, Y Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrinavß3. Bioorg Med Chem Lett23:340-5 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Phospholipase A2, membrane associated

Name:

Phospholipase A2, membrane associated

Synonyms:

Type:

Hydrolase

Mol. Mass.:

16101.20

Organism:

Homo sapiens (Human)

Description:

The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.

Residue:

144

Sequence:

MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

BDBM50428492

n/a

Name

BDBM50428492

Synonyms:

CHEMBL2335197

Type

Small organic molecule

Emp. Form.

C25H30N10O6S

Mol. Mass.

598.634

SMILES

Cc1nc(NC(=O)c2ccccc2)sc1-c1cc([nH]n1)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(O)=O |r,wU:27.29,(52.25,-6.63,;50.72,-6.48,;49.69,-7.62,;48.28,-6.99,;46.95,-7.77,;45.61,-7,;45.61,-5.46,;44.28,-7.77,;42.95,-6.99,;41.61,-7.77,;41.61,-9.31,;42.96,-10.07,;44.29,-9.3,;48.44,-5.46,;49.95,-5.14,;50.57,-3.73,;52.08,-3.41,;52.23,-1.87,;50.83,-1.26,;49.8,-2.4,;53.56,-1.11,;53.56,.43,;54.9,-1.87,;56.24,-1.1,;57.57,-1.87,;57.57,-3.41,;58.9,-1.1,;60.23,-1.87,;60.23,-3.41,;61.57,-4.18,;61.57,-5.72,;62.91,-6.49,;62.91,-8.03,;61.57,-8.81,;64.24,-8.81,;61.57,-1.1,;61.57,.44,;62.91,-1.87,;64.24,-1.1,;65.58,-1.87,;66.91,-1.1,;65.58,-3.41,)|

Structure