| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50434076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_958429 (CHEMBL2382937) |
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| IC50 | 12±n/a nM |
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| Citation |  Limpachayaporn, P; Wagner, S; Kopka, K; Hermann, S; Schäfers, M; Haufe, G Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography. J Med Chem56:4509-20 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50434076 |
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| n/a |
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| Name | BDBM50434076 |
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| Synonyms: | CHEMBL2381343 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23FN2O6S |
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| Mol. Mass. | 414.448 |
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| SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(CC[C@H](F)CO)C(=O)C(=O)c2c1 |r| |
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| Structure | 
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