| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50439678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_977787 (CHEMBL2421008) |
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| IC50 | 2.6±n/a nM |
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| Citation |  Galli, U; Travelli, C; Massarotti, A; Fakhfouri, G; Rahimian, R; Tron, GC; Genazzani, AA Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J Med Chem56:6279-96 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM50439678 |
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| n/a |
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| Name | BDBM50439678 |
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| Synonyms: | CHEMBL2417789 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16ClN5O2S |
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| Mol. Mass. | 425.891 |
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| SMILES | Clc1cccc(c1)S(=O)(=O)c1ccc(CNC(NC#N)=Nc2ccncc2)cc1 |w:20.21| |
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| Structure | 
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