| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier organic anion transporter family member 1B3 |
|---|
| Ligand | BDBM38549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1265866 (CHEMBL3039492) |
|---|
| IC50 | 1230±n/a nM |
|---|
| Citation |  De Bruyn, T; van Westen, GJ; Ijzerman, AP; Stieger, B; de Witte, P; Augustijns, PF; Annaert, PP Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol83:1257-67 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier organic anion transporter family member 1B3 |
|---|
| Name: | Solute carrier organic anion transporter family member 1B3 |
|---|
| Synonyms: | LST2 | OATP1B3 | OATP8 | Organic Anion Transporter OATP1B3 | SLC21A8 | SLCO1B3 | SO1B3_HUMAN | Solute carrier organic anion transporter family member 1B3 | Solute carrier organic anion transporter family member 1B3 (OATP1B3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 77425.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NPD5 |
|---|
| Residue: | 702 |
|---|
| Sequence: | MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFD
ISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGY
YRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNML
RGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYV
DLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLK
TNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVF
KYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFL
FQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGIT
YLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAI
QVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCM
KWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASD
NERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
|
|
|
|---|
| BDBM38549 |
|---|
| n/a |
|---|
| Name | BDBM38549 |
|---|
| Synonyms: | 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino]ethoxy]ethanol | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol | 4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid | 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-2-naphthoic acid | CHEMBL170358 | CHEMBL177880 | HYDROXYZINE PAMOATE | MLS000028605 | Pamoic acid | SMR000058728 | US11744839, Compound of formula 8 | cid_25096 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H16O6 |
|---|
| Mol. Mass. | 388.3695 |
|---|
| SMILES | OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
