| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 |
|---|
| Ligand | BDBM50448337 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1293851 (CHEMBL3123527) |
|---|
| IC50 | 3.2±n/a nM |
|---|
| Citation |  Keith, JM; Hawryluk, N; Apodaca, RL; Chambers, A; Pierce, JM; Seierstad, M; Palmer, JA; Webb, M; Karbarz, MJ; Scott, BP; Wilson, SJ; Luo, L; Wennerholm, ML; Chang, L; Rizzolio, M; Chaplan, SR; Breitenbucher, JG 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett24:1280-4 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fatty-acid amide hydrolase 1 |
|---|
| Name: | Fatty-acid amide hydrolase 1 |
|---|
| Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63071.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00519 |
|---|
| Residue: | 579 |
|---|
| Sequence: | MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
|
|
|
|---|
| BDBM50448337 |
|---|
| n/a |
|---|
| Name | BDBM50448337 |
|---|
| Synonyms: | CHEMBL3121116 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18FN3O2 |
|---|
| Mol. Mass. | 351.3742 |
|---|
| SMILES | CC(=O)c1ccc(cc1F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
