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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 2 | ||
| Ligand | BDBM50009432 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1335972 (CHEMBL3239093) | ||
| IC50 | 9700±n/a nM | ||
| Citation |  Zhou, G; Ting, PC; Wishart, G; Zorn, N; Aslanian, RG; Lin, M; Smith, M; Walker, SS; Cook, J; Van Heek, M; Lachowicz, J Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors. Bioorg Med Chem Lett24:1790-4 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 2 | |||
| Name: | Sterol O-acyltransferase 2 | ||
| Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 59912.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75908 | ||
| Residue: | 522 | ||
| Sequence: |
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| BDBM50009432 | |||
| n/a | |||
| Name | BDBM50009432 | ||
| Synonyms: | CHEMBL3233884 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H30N2O4 | ||
| Mol. Mass. | 470.5595 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:7.10,wD:4.3,(49.67,-49.46,;49.66,-47.92,;50.99,-47.14,;48.32,-47.16,;46.99,-47.94,;45.65,-47.18,;44.32,-47.96,;44.34,-49.5,;45.68,-50.26,;47,-49.48,;43.01,-50.28,;43.03,-51.82,;41.7,-52.6,;40.36,-51.84,;40.34,-50.31,;41.66,-49.52,;39.03,-52.62,;37.69,-51.86,;36.36,-52.63,;36.39,-54.19,;35.07,-54.96,;35.08,-56.5,;36.42,-57.26,;37.75,-56.48,;37.73,-54.94,;39.05,-54.15,;33.73,-54.2,;33.72,-52.66,;32.4,-54.98,;31.06,-54.22,;31.05,-52.69,;29.71,-51.93,;28.38,-52.71,;28.4,-54.26,;29.74,-55.01,)| | ||
| Structure | 
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