| Reaction Details |
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 | Report a problem with these data |
| Target | Free fatty acid receptor 2 |
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| Ligand | BDBM50032293 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440135 (CHEMBL3382548) |
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| IC50 | 3350±n/a nM |
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| Citation |  Pizzonero, M; Dupont, S; Babel, M; Beaumont, S; Bienvenu, N; Blanqué, R; Cherel, L; Christophe, T; Crescenzi, B; De Lemos, E; Delerive, P; Deprez, P; De Vos, S; Djata, F; Fletcher, S; Kopiejewski, S; L'Ebraly, C; Lefrançois, JM; Lavazais, S; Manioc, M; Nelles, L; Oste, L; Polancec, D; Quénéhen, V; Soulas, F; Triballeau, N; van der Aar, EM; Vandeghinste, N; Wakselman, E; Brys, R; Saniere, L Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem57:10044-57 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Free fatty acid receptor 2 |
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| Name: | Free fatty acid receptor 2 |
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| Synonyms: | FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37156.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508993 |
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| Residue: | 330 |
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| Sequence: | MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLL
LLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS
RRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVR
LELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNV
SHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLG
RRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
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| BDBM50032293 |
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| n/a |
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| Name | BDBM50032293 |
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| Synonyms: | CHEMBL3352828 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20Cl2N2O3S |
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| Mol. Mass. | 427.345 |
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| SMILES | COc1c(Cl)scc1C(=O)N1CCC1(C)C(=O)N(C)Cc1ccc(Cl)cc1 |
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| Structure | 
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