| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin glutathione reductase |
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| Ligand | BDBM50049864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1455608 (CHEMBL3365309) |
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| IC50 | 8500±n/a nM |
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| Citation |  Guglielmo, S; Cortese, D; Vottero, F; Rolando, B; Kommer, VP; Williams, DL; Fruttero, R; Gasco, A New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem84:135-45 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin glutathione reductase |
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| Name: | Thioredoxin glutathione reductase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64881.48 |
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| Organism: | Schistosoma mansoni |
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| Description: | ChEMBL_1455608 |
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| Residue: | 597 |
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| Sequence: | MPPADGTSQWLRKTVDSAAVILFSKTTCPYCKKVKDVLAEAKIKHATIELDQLSNGSAIQ
KCLASFSKIETVPQMFVRGKFIGDSQTVLKYYSNDELAGIVNESKYDYDLIVIGGGSGGL
AAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMHQAGLLSHALEDAEH
FGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNAKGRLISPHEVQITD
KNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPYFPGKTLVIGASYVALE
CAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEIKQLKVVDT
ENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCETVGVKLDKNGRVVCTDD
EQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATELTDYSNVATTVFTPLEYG
ACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDNVCYMKLVCRKSDNMRVLGLHVL
GPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTTLHVTKKSGVSPIVSGCG
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| BDBM50049864 |
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| n/a |
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| Name | BDBM50049864 |
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| Synonyms: | CHEMBL3322356 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N4O8S |
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| Mol. Mass. | 610.678 |
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| SMILES | [O-][n+]1onc(OCCCOc2ccc3CCN4C(CN(CC4=O)C(=O)C4CCCCC4)c3c2)c1S(=O)(=O)c1ccccc1 |
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| Structure | 
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