Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50054094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1455573 (CHEMBL3364950) |
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EC50 | 776±n/a nM |
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Citation | Hong, FT; Norman, MH; Ashton, KS; Bartberger, MD; Chen, J; Chmait, S; Cupples, R; Fotsch, C; Jordan, SR; Lloyd, DJ; Sivits, G; Tadesse, S; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket. J Med Chem57:5949-64 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | Gck | Gk | Glucokinase | HK IV | HK4 | HXK4_MOUSE | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52075.40 |
Organism: | Mus musculus (Mouse) |
Description: | P52792 |
Residue: | 465 |
Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGE
LVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPS
VADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50054094 |
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n/a |
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Name | BDBM50054094 |
Synonyms: | CHEMBL3319541 |
Type | Small organic molecule |
Emp. Form. | C23H21F6N5O3S |
Mol. Mass. | 561.5 |
SMILES | Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ncc(cc1-c1ccccc1)C(O)(C(F)(F)F)C(F)(F)F |
Structure |
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