| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Ligand | BDBM50069501 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1466787 (CHEMBL3405543) |
|---|
| IC50 | 549541±n/a nM |
|---|
| Citation |  Vogensen, SB; Jørgensen, L; Madsen, KK; Jurik, A; Borkar, N; Rosatelli, E; Nielsen, B; Ecker, GF; Schousboe, A; Clausen, RP Structure activity relationship of selective GABA uptake inhibitors. Bioorg Med Chem23:2480-8 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Synonyms: | GABA transporter | GAT-3 | Gabt3 | Gabt4 | Gat-4 | Gat3 | Gat4 | S6A11_MOUSE | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Sodium- and chloride-dependent GABA transporter 4 | Solute carrier family 6 member 11 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69962.73 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1460090 |
|---|
| Residue: | 627 |
|---|
| Sequence: | MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAG
EIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRV
CPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQK
LNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWK
GTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQ
IFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV
PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM
YPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV
CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYT
YPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPR
TVTVNDCEAKVKGDGTISAITEKETHF
|
|
|
|---|
| BDBM50069501 |
|---|
| n/a |
|---|
| Name | BDBM50069501 |
|---|
| Synonyms: | CHEMBL3403554 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29NO2S2 |
|---|
| Mol. Mass. | 403.601 |
|---|
| SMILES | [#6]-[#7](-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6@@H]-1-[#6]-[#6]-[#6]-[#6]-[#6@H]-1-[#6](-[#8])=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
