| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 1A |
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| Ligand | BDBM50373071 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468710 (CHEMBL3414053) |
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| IC50 | 22000±n/a nM |
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| Citation |  Rodríguez-Sanz, A; Sánchez-Alonso, P; Bellón, T; Alajarín, R; Martínez-Cabeza, V; Selgas, R; Vaquero, JJ; Álvarez-Builla, J Synthesis and biological evaluation of pyridazino[1',6':1,2]pyrido[3,4-b]indolinium and pyridazino[1,6-a]benzimidazolium salts as anti-inflammatory agents. Eur J Med Chem93:83-92 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 1A |
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| Name: | Tumor necrosis factor receptor superfamily member 1A |
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| Synonyms: | CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50495.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1509419 |
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| Residue: | 455 |
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| Sequence: | MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
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| BDBM50373071 |
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| n/a |
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| Name | BDBM50373071 |
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| Synonyms: | CHEMBL255489 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32F3N3O2 |
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| Mol. Mass. | 547.6106 |
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| SMILES | CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12 |
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| Structure | 
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