| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50075962 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473804 (CHEMBL3418529) |
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| IC50 | 1500±n/a nM |
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| Citation |  Huleatt, PB; Khoo, ML; Chua, YY; Tan, TW; Liew, RS; Balogh, B; Deme, R; Gölöncsér, F; Magyar, K; Sheela, DP; Ho, HK; Sperlágh, B; Mátyus, P; Chai, CL Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease. J Med Chem58:1400-19 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58469.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P19643 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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| BDBM50075962 |
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| n/a |
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| Name | BDBM50075962 |
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| Synonyms: | CHEMBL3415800 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19NO5 |
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| Mol. Mass. | 305.3258 |
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| SMILES | OC(=O)C([O-])=O.COc1cccc(c1)C(=C)C[NH+](C)CC#C |
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| Structure | 
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