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TargetSynaptic vesicular amine transporter
LigandBDBM50080827
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1504550 (CHEMBL3591146)
Ki 45±n/a nM
Citation Ding, D; Nickell, JR; Dwoskin, LP; Crooks, PA Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett25:2613-6 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Synaptic vesicular amine transporter
Name:Synaptic vesicular amine transporter
Synonyms:Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:Protein
Mol. Mass.:55689.58
Organism:Rattus norvegicus (Rat)
Description:Q01827
Residue:515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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  Blast E-value cutoff:
BDBM50080827
n/a
NameBDBM50080827
Synonyms:(2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,6R)-1-Methyl-2,6-diphenethyl-piperidine | CHEMBL1085811 | CHEMBL333465 | Lobelane | cis-N-methyl-2,6-diphenethylpiperidine
TypeSmall organic molecule
Emp. Form.C22H29N
Mol. Mass.307.4724
SMILESCN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r|
Structure
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