Reaction Details |
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Target | Transient receptor potential cation channel subfamily V member 4 |
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Ligand | BDBM50117641 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1514408 (CHEMBL3615487) |
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IC50 | 5740±n/a nM |
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Citation | Wei, ZL; Nguyen, MT; O'Mahony, DJ; Acevedo, A; Zipfel, S; Zhang, Q; Liu, L; Dourado, M; Chi, C; Yip, V; DeFalco, J; Gustafson, A; Emerling, DE; Kelly, MG; Kincaid, J; Vincent, F; Duncton, MA Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett25:4011-5 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily V member 4 |
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Name: | Transient receptor potential cation channel subfamily V member 4 |
Synonyms: | TRPV4_RAT | Trpv4 | Vanilloid receptor | Vroac |
Type: | PROTEIN |
Mol. Mass.: | 98016.72 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1514408 |
Residue: | 871 |
Sequence: | MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDN
KRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSYLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDS
NLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLLTGVLFFFTSIKDLFMKKCPGV
NSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPAC
RDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDE
VVVPLDNLGNPNCDGHQQGYAPKWRAEDAPL
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BDBM50117641 |
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n/a |
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Name | BDBM50117641 |
Synonyms: | CHEMBL3613633 |
Type | Small organic molecule |
Emp. Form. | C16H15F3N2O3S |
Mol. Mass. | 372.362 |
SMILES | CN(C)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1 |
Structure |
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