Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50121656 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1516442 (CHEMBL3619460) |
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IC50 | 52120±n/a nM |
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Citation | Hu, Y; Li, S; Liu, F; Geng, L; Shu, X; Zhang, J Discovery of novel nonpeptide allosteric inhibitors interrupting the interaction of CDK2/cyclin A3 by virtual screening and bioassays. Bioorg Med Chem Lett25:4069-73 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50121656 |
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n/a |
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Name | BDBM50121656 |
Synonyms: | CHEMBL3616869 |
Type | Small organic molecule |
Emp. Form. | C14H12N2O3S |
Mol. Mass. | 288.322 |
SMILES | CSc1ccc(\C=N\c2cc(ccc2O)[N+]([O-])=O)cc1 |
Structure |
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