| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50168029 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575480 (CHEMBL3802768) |
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| IC50 | 3800±n/a nM |
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| Citation |  Clark, DE; Waszkowycz, B; Wong, M; Lockey, PM; Adalbert, R; Gilley, J; Clark, J; Coleman, MP Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies. Bioorg Med Chem Lett26:2920-2926 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM50168029 |
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| n/a |
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| Name | BDBM50168029 |
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| Synonyms: | CHEMBL3799664 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N6O2 |
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| Mol. Mass. | 400.4332 |
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| SMILES | O=C(N1CCN(CC1)C(=O)c1cc2ccccc2[nH]1)c1cc(n[nH]1)-c1cccnc1 |
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| Structure | 
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