Reaction Details |
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Target | Poly [ADP-ribose] polymerase 2 |
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Ligand | BDBM50444543 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1590057 (CHEMBL3829027) |
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IC50 | 10529±n/a nM |
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Citation | Nathubhai, A; Haikarainen, T; Hayward, PC; Muñoz-Descalzo, S; Thompson, AS; Lloyd, MD; Lehtiö, L; Threadgill, MD Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem118:316-27 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Poly [ADP-ribose] polymerase 2 |
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Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
Type: | Enzyme |
Mol. Mass.: | 66225.70 |
Organism: | Homo sapiens (Human) |
Description: | Q9UGN5 |
Residue: | 583 |
Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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BDBM50444543 |
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n/a |
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Name | BDBM50444543 |
Synonyms: | CHEMBL3098937 |
Type | Small organic molecule |
Emp. Form. | C15H11BrN2O |
Mol. Mass. | 315.165 |
SMILES | Cc1cccc2c1nc([nH]c2=O)-c1ccc(Br)cc1 |
Structure |
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