Reaction Details |
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Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
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Ligand | BDBM50195476 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1617799 (CHEMBL3859868) |
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EC50 | 3.0±n/a nM |
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Citation | Cameron, KO; Kurumbail, RG Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators. Bioorg Med Chem Lett26:5139-5148 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
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Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
Synonyms: | 5'-AMP-activated protein kinase Complex 1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1 | AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 | AMPK alpha1/beta1/gamma1 | AMPK complex 1 (alpha-1,beta-1,gamma-1) | Adenosine monophosphate-activated protein kinase (AMPK gamma 1, beta 1 and alpha 1) | Recombinant AMPK alpha1/beta1/gamma1 complex |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 0 components. |
Component 1 |
Name: | 5'-AMP-activated protein kinase subunit beta-1 |
Synonyms: | 5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1 |
Type: | n/a |
Mol. Mass.: | 30380.94 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y478 |
Residue: | 270 |
Sequence: | MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
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Component 2 |
Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
Synonyms: | 5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1 |
Type: | n/a |
Mol. Mass.: | 37581.44 |
Organism: | Homo sapiens (Human) |
Description: | P54619 |
Residue: | 331 |
Sequence: | METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
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Component 3 |
Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
Synonyms: | AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1 |
Type: | Protein |
Mol. Mass.: | 64023.62 |
Organism: | Homo sapiens (Human) |
Description: | Q13131 |
Residue: | 559 |
Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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BDBM50195476 |
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n/a |
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Name | BDBM50195476 |
Synonyms: | CHEMBL3938731 |
Type | Small organic molecule |
Emp. Form. | C25H22ClFN4O6S |
Mol. Mass. | 560.982 |
SMILES | [H][C@]12OC[C@@H](Oc3nc4nc(c(Cl)cc4[nH]3)-c3ccc(cc3)-c3ccc(NS(C)(=O)=O)cc3F)[C@@]1([H])OC[C@H]2O |r| |
Structure |
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