| Reaction Details |
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 | Report a problem with these data |
| Target | NACHT, LRR and PYD domains-containing protein 3 |
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| Ligand | BDBM50155926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621767 (CHEMBL3864050) |
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| IC50 | 7.5±n/a nM |
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| Citation |  Salla, M; Butler, MS; Pelingon, R; Kaeslin, G; Croker, DE; Reid, JC; Baek, JM; Bernhardt, PV; Gillam, EM; Cooper, MA; Robertson, AA Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. ACS Med Chem Lett7:1034-1038 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NACHT, LRR and PYD domains-containing protein 3 |
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| Name: | NACHT, LRR and PYD domains-containing protein 3 |
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| Synonyms: | Cias1 | Cias1 | Cold autoinflammatory syndrome 1 protein homolog | Cryopyrin | Mast cell maturation-associated-inducible protein 1 | Mmig1 | NACHT, LRR and PYD domains-containing protein 3 | NLRP3_MOUSE | Nalp3 | Nlrp3 | PYRIN-containing APAF1-like protein 1 | Pypaf1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 118281.75 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116758 |
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| Residue: | 1033 |
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| Sequence: | MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYL
SRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQERE
HELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWA
LGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGF
DELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDH
PRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQ
QMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILF
EECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGET
VRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMD
HVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNC
CLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLS
HQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSAC
CQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSA
LTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLST
ILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQE
EKPELTIVFEISW
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| BDBM50155926 |
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| n/a |
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| Name | BDBM50155926 |
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| Synonyms: | CHEMBL3183703 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O5S |
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| Mol. Mass. | 404.48 |
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| SMILES | CC(C)(O)c1coc(c1)S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12 |
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| Structure | 
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