Reaction Details | |||
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Target | Free fatty acid receptor 4 | ||
Ligand | BDBM50207069 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1629516 (CHEMBL3872142) | ||
EC50 | 17±n/a nM | ||
Citation | Adams, GL; Velazquez, F; Jayne, C; Shah, U; Miao, S; Ashley, ER; Madeira, M; Akiyama, TE; Di Salvo, J; Suzuki, T; Wang, N; Truong, Q; Gilbert, E; Zhou, D; Verras, A; Kirkland, M; Pachanski, M; Powles, M; Yin, W; Ujjainwalla, F; Venkatraman, S; Edmondson, SD Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with ACS Med Chem Lett8:96-101 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Free fatty acid receptor 4 | |||
Name: | Free fatty acid receptor 4 | ||
Synonyms: | FFAR4 | FFAR4_HUMAN | G-protein coupled receptor 120 | G-protein coupled receptor 129 | G-protein coupled receptor GT01 | G-protein coupled receptor PGR4 | GPR120 | GPR129 | O3FAR1 | Omega-3 fatty acid receptor 1 | PGR4 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 42256.91 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1508994 | ||
Residue: | 377 | ||
Sequence: |
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BDBM50207069 | |||
n/a | |||
Name | BDBM50207069 | ||
Synonyms: | CHEMBL3959068 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H24F2O5 | ||
Mol. Mass. | 430.4412 | ||
SMILES | [H][C@]1(C[C@@]1([H])[C@@]1([H])CCc2cc(ccc2O1)-c1cc(O[C@H]2C[C@@H](C2)OC)cc(F)c1F)C(O)=O |r,wU:5.6,1.0,20.22,wD:3.4,22.27,(25.35,-14.1,;25.76,-15.6,;25.75,-17.14,;24.43,-16.36,;24.41,-17.9,;23.08,-15.59,;22.96,-17.12,;23.09,-14.03,;21.74,-13.25,;20.4,-14.03,;19.07,-13.27,;17.74,-14.04,;17.73,-15.59,;19.06,-16.36,;20.39,-15.59,;21.74,-16.36,;16.4,-13.27,;15.07,-14.04,;13.74,-13.27,;12.4,-14.05,;11.07,-13.29,;9.59,-13.69,;9.19,-12.21,;10.67,-11.8,;7.86,-11.45,;7.86,-9.92,;13.73,-11.73,;15.07,-10.95,;15.07,-9.43,;16.41,-11.72,;17.74,-10.95,;27.1,-16.37,;27.09,-17.91,;28.43,-15.6,)| | ||
Structure |