| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM50235954 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658402 (CHEMBL4008014) |
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| IC50 | 84±n/a nM |
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| Citation |  Martín-Martínez, M; Pérez-Gordillo, FL; Álvarez de la Rosa, D; Rodríguez, Y; Gerona-Navarro, G; González-Muñiz, R; Zhou, MM Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects. J Med Chem60:2629-2650 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR_RAT | MR | Mineralocorticoid Receptor (MR) | Mineralocorticoid receptor | Mlr | Nr3c2 | Nuclear receptor subfamily 3 group C member 2 | mineralocorticoid |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 106748.15 |
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| Organism: | RAT |
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| Description: | mineralocorticoid 0 RAT::P22199 |
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| Residue: | 981 |
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| Sequence: | METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNST
QGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYD
QQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAI
VKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPS
VENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSP
ANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVV
PSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISP
SSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPG
FDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSP
RDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRP
SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR
LQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSAL
VPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKW
AKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQS
AMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKEL
RKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEI
ITDQLPKVESGNAKPLYFHRK
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| BDBM50235954 |
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| n/a |
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| Name | BDBM50235954 |
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| Synonyms: | CHEMBL4075017 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O5S2 |
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| Mol. Mass. | 494.583 |
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| SMILES | COc1cc(NC(=O)c2ccc(c(CO)c2)-c2ccccc2-c2cccs2)ccc1S(N)(=O)=O |
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| Structure | 
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