| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 1/2 |
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| Ligand | BDBM50237157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1659949 (CHEMBL4009561) |
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| IC50 | >100000±n/a nM |
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| Citation |  Al-Sabi, A; Daly, D; Hoefer, P; Kinsella, GK; Metais, C; Pickering, M; Herron, C; Kaza, SK; Nolan, K; Dolly, JO A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction. J Med Chem60:2245-2256 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 1/2 |
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| Name: | Potassium voltage-gated channel subfamily A member 1/2 |
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| Synonyms: | Potassium voltage-gated channel subfamily A member 1/2 (Kv1.1/Kv1.2) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1659948 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Potassium voltage-gated channel subfamily A member 1 |
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| Synonyms: | KCNA1_RAT | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | RBKI | RCK1 | Voltage-gated potassium channel subunit Kv1.1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56364.13 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_117743 |
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| Residue: | 495 |
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| Sequence: | MTVMSGENADEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
IVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRF
FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
GEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTA
TDQNCVNKSKLLTDV
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| Component 2 |
| Name: | Potassium voltage-gated channel subfamily A member 2 |
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| Synonyms: | KCNA2_RAT | Kcna2 | Potassium voltage-gated channel subfamily A member 2 | RAK | RBK2 | RCK5 | Voltage-gated potassium channel subunit Kv1.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56679.97 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_117743 |
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| Residue: | 499 |
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| Sequence: | MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG
DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE
EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF
CLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR
FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR
VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPS
IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE
TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA
NCTLANTNYVNITKMLTDV
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| BDBM50237157 |
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| n/a |
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| Name | BDBM50237157 |
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| Synonyms: | CHEMBL4079366 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36Cl2N6O2 |
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| Mol. Mass. | 571.541 |
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| SMILES | Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1 |
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| Structure | 
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