Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
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Ligand | BDBM85435 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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Temperature | 298.15±0 K |
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IC50 | 5±0.0 nM |
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Citation | Norcini, G; Morazzoni, G; Pocchiari, F; Santangelo, F; Semeraro, C Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position. J Enzym Inhib12:155-60 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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BDBM85435 |
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n/a |
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Name | BDBM85435 |
Synonyms: | NEP inhibitor, 6o |
Type | Small organic molecule |
Emp. Form. | C16H18N2O4S |
Mol. Mass. | 334.39 |
SMILES | COc1cccc(CC(CS)C(=O)Nc2c[nH]c(c2)C(O)=O)c1 |
Structure |
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