| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM85530 |
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| Substrate/Competitor | n/a |
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| Ki | 2316±n/a nM |
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| Comments | PDSP_1358 |
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| Citation |  Rothman, RB; Baumann, MH; Savage, JE; Rauser, L; McBride, A; Hufeisen, SJ; Roth, BL Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation102:2836-41 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52852.05 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cortex membranes 5-HT2A receptors. |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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| BDBM85530 |
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| n/a |
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| Name | BDBM85530 |
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| Synonyms: | Nor-d-fenfluramine | Nor-dexfenfluramine | Norfenfluramine | Norfenfluramine (+) | Norfenfluramine (-) | d-Norfenfluramine |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12F3N |
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| Mol. Mass. | 203.2042 |
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| SMILES | C[C@H](N)Cc1cccc(c1)C(F)(F)F |
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| Structure | 
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